Hairy cell leukemia. Never in nodes. BLOOD: mimics aplastic anemia (has characteristic MONOCYTOPENIA and neutropenia- reason you would die from it). Very few neoplastic cells in blood. DO NOT DIAGNOSE if there are monocytes. Classic cell morphology = bigger, with nucleus 2x size of normal one and the cell size is very uniform, no transformed cells. Nuclei can be round, oval, RENIFORM, or bilobed. Chromatin is very distinct ground glass and NO
Ruptured venule. Coloured scanning electron micrograph (SEM) showing stacks (rouleaux) of red blood cells exposed inside a torn venule. A venule is a very small blood vessel in the microcirculation that allows deoxygenated blood to return from the capillary beds to the larger blood vessels (veins). Red blood cells are the most abundant cell in the blood. They have no nucleus and are about 7 micrometers across. Magnification: x2300 when printed at 10 centimetres wide.
Normal body-type gastric mucosa. Autoimmune chronic atrophic gastritis is restricted to body (not antrum). Antiparietal cell antibodies and anti-IF antibodies, +/- pernicious anemia. Destroy acid-producing parietal cells, leading to achlorhydria, which in turn stimulates gastrin leading to hypergastrinemia and ulcers.
B cell defects. 1. Bruton (X-linked), recurrent pyogenic, males, 6 months. GIARDIA. No plasma cells in GI biopsies. Very low serum IgG. Normal immunity to viral and fungal, increased risk of lymphomas. Atk gene (Tyrosine kinase). 2. CVID low overall serum Ig of every class and some T cell issues too. RESPIRATORY TRACT, Giardia, bronchiectasis. Normal number of B cells but cannot differentiate into plasma cells. 3. Selective IgA. 4. Job (hyper
Scrotum. Granular cell tumor. S100 positive, CD68 positive, inhibin positive. Lysosomes on EM. uvenile xanthogranuloma features histiocytic cells which merge with those with features of Touton-like giant cells. This lesion labels for CD68, but not for S100 or CD1a. Langerhans histiocytosis is composed of cells with more reniform nuclei, and the lesional cells label for CD1a.
Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini
Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam)
Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm)
Signet ring cells or intercellular glandular lumens
"A water break? Water is for cowards. Water makes you weak. Water is for washing blood off that uniform and you don't get no blood on my uniform!"
For the Home
CLL/SLL. Smudge cells (EDTA), usually <30K, prolymphs <10%. BM is commonly involved at presentation- nodular (better), diffuse (worse prognosis) or interstitial. IHC: CD19, CD20 DIM**, CD5 and CD23 (also 79, 22, 43, and 11c). Negative for FMC-7, 10, bcl1 and bcl6. bcl2 expressed in all B cell neoplasms pretty much. CD38 and/or ZAP-70 = UNMUTATED and WORSE prognosis. (An increase in polyclonal lymphs that coexpress CD5 and CD19 is sometimes seen in RA, HCV and post-BMT). Deletion13q14 is most common and is best prognosis (Trisomy 12 is intermediate). Bad ones are del11 and del 17. Transformation to PLL (11-55%) is heralded by weaker 5 and 23, stronger 20. PROGNOSIS = Rai and Binet staging. Worse if you have B symptoms, HSM, anemia or thromboytopenia, high doubling time, atypical morphology.
Lung cells. Immunofluorescence light micrograph of pulmonary endothelial cells. Endothelial cells are specialized epithelial cells that line the inner surface of blood vessels. Nuclei, which contain the cell's genetic information, are purple; actin filaments, which are major components of the cytoskeleton, are cyan; mitochondria, which generate energy for the cell, are white. © Dr. Torsten Wittmann / Science Source #lungcells #pulmonary #micrograph #sciencephotos #stockimages #sciencesource
MONOCYTOPENIA = hairy cell leukemia. It also heralds the onset of neutropenia in chemo.
"Thalassemic Indices" = ELEVATED RBC, low MCV, low Hct, and normal RDW. If the degree of anemia doesn't quite fit with the microcytosis, think of thalassemia (vs. IDA in which the anemia and microcytosis do fit). Smear shows occ target cells and BASOPHILIC stippling.
Adenocarcinoma. The cell in focus is comprised of a large nucleus, promininent nucleoli with an eccentric cytoplasm, suggesting glandular differentiation. Another fragment is shown with cells in a cohesive group with subtle cell borders. The nuclear outlines are irregular, and each contains a prominent nucleoli. The degree of atypia is consistent with an adenocarcinoma. The clean smear background is suggestive of a metastasis.
Hepatoblastoma. Three cell types. undifferentiated (small cells reminiscent of neuroblastoma or Wilms tumor), embryonal cells (slightly more mature cells with large nuclei, scant cytoplasm, arranged in some architectural pattern), and fetal cells (larger cells with abundant cytoplasm, smaller than mature hepatocytes).
Echinocytes (aka burr cells) in a peripheral blood smear. Note the uniform distribution of projections on the surface of the cell. Not to be confused with spur cells. Seen in chronic renal failure.
HbC disease beta6glu--> lys). CA is 40-50% in C band (A2 and C). Asymptomatic, may have target cells. CC is 90% C, 7% F, 3% A2 and NO A. Mild hemolytic anemia, splenomeg, and many targets! Also have these rod shaped crystals, esp after splenectomy.
Coriander (Cilantro) is considered both an herb & a spice since both its leaves and its seeds are used as a condiment. Some of the acids present in coriander, including ascorbic acid are very effective in reducing the cholesterol level in the blood while reducing the cholesterol deposition along the inner walls of the arteries & veins. Other benefits include anemia, swellings & digestion. #dherbs #healthtips
Understanding Sleep Apnea Infographic - I have sleep apnea and when first diagnosed I wouldn't wear my c-pap machine at night like I was supposed to. Over a period of a year my red and white blood cell counts increased to way above abnormal. They thought I might have leukemia. Come to find out it was just lack of oxygen to my cells from not wearing my c-pap at night. I was slowly killing myself. Now I wear it every night!
Fixing uneven joins when you are welding letters together. You just need to adjust a few nodes and it is really pretty easy to do. (EDIT POINTS)
Human blood cells, coloured scanning electron micrograph (SEM). Seen here are platelets (small, roundish) and a neutrophil white blood cell (large, whitish).
Migrating cancer cell. Coloured scanning electron micrograph (SEM) of a cultured cancer cell moving (metastasising) through a hole in a support film. Numerous pseudopodia (arm-like), fillipodia (thread-like) and surface blebs (lumps) can be seen. These features are characteristic of highly mobile cells, and enable cancerous cells to spread rapidly around the body, and invade other organs and tissues (metastasis).
There is so much truth in this. Big girls are so soft and feminine too. I know this guy loves that. Feels very secure and safe in a bigger woman's arms and being next to her curvy large soft body. Just love cuddling with my wife for this very reason. :-)
Better Builder's Deck Here, a basic builder's deck with few details is transformed into a stunning and inviting outdoor living space with just a few affordable upgrades.
My Outdoor Love
DARIER's Disease = This solitary keratotic papule has a somewhat endophytic growth pattern, with a central plug of keratin. There is both acantholysis and dyskeratosis. There is suprabasal acantholysis over a papillomatous superficial dermis. Above the suprabasal acantholysis, there are large, eosinophilic, rounded suprabasal cells with perinuclear halos (Corps Ronds). Above these are small dark cells with pyknotic nuclei and a millet-seed-like