Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini
Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam)
Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm)
Signet ring cells or intercellular glandular lumens by rochelle
rochelle
rochelle Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam) Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm) Signet ring cells or intercellular glandular lumens
bargain
Mesothelioma = large complex cell clusters with KNOBBY border. Cell in cell arrangements. Single cells with dense perinuclear cytoplasm and lacy cytoplasm.  POS for calretinin, EMA, Alcian blue, CK 5/6, CAM 5.2 and only PAS (glycogen).  Neg for PAS-D (glycogen is dissolved), BerEp4, B72.3, CD15, mucicarmine. Have long branching slender microvilli on EM. Can have collagen balls and lymphs. by alma
alma
alma Mesothelioma = large complex cell clusters with KNOBBY border. Cell in cell arrangements. Single cells with dense perinuclear cytoplasm and lacy cytoplasm. POS for calretinin, EMA, Alcian blue, CK 5/6, CAM 5.2 and only PAS (glycogen). Neg for PAS-D (glycogen is dissolved), BerEp4, B72.3, CD15, mucicarmine. Have long branching slender microvilli on EM. Can have collagen balls and lymphs.
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Scrotum. Granular cell tumor. S100 positive, CD68 positive, inhibin positive. Lysosomes on EM. uvenile xanthogranuloma features histiocytic cells which merge with those with features of Touton-like giant cells. This lesion labels for CD68, but not for S100 or CD1a. Langerhans histiocytosis is composed of cells with more reniform nuclei, and the lesional cells label for CD1a. by carolina
carolina
carolina Scrotum. Granular cell tumor. S100 positive, CD68 positive, inhibin positive. Lysosomes on EM. uvenile xanthogranuloma features histiocytic cells which merge with those with features of Touton-like giant cells. This lesion labels for CD68, but not for S100 or CD1a. Langerhans histiocytosis is composed of cells with more reniform nuclei, and the lesional cells label for CD1a.
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Adenocarcinoma. The cell in focus is comprised of a large nucleus, promininent nucleoli with an eccentric cytoplasm, suggesting glandular differentiation. Another fragment is shown with cells in a cohesive group with subtle cell borders. The nuclear outlines are irregular, and each contains a prominent nucleoli. The degree of atypia is consistent with an adenocarcinoma. The clean smear background is suggestive of a metastasis. by brittney
brittney
brittney Adenocarcinoma. The cell in focus is comprised of a large nucleus, promininent nucleoli with an eccentric cytoplasm, suggesting glandular differentiation. Another fragment is shown with cells in a cohesive group with subtle cell borders. The nuclear outlines are irregular, and each contains a prominent nucleoli. The degree of atypia is consistent with an adenocarcinoma. The clean smear background is suggestive of a metastasis.
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Hepatoblastoma. Three cell types. undifferentiated (small cells reminiscent of neuroblastoma or Wilms tumor), embryonal cells (slightly more mature cells with large nuclei, scant cytoplasm, arranged in some architectural pattern), and fetal cells (larger cells with abundant cytoplasm, smaller than mature hepatocytes). by marcie
marcie
marcie Hepatoblastoma. Three cell types. undifferentiated (small cells reminiscent of neuroblastoma or Wilms tumor), embryonal cells (slightly more mature cells with large nuclei, scant cytoplasm, arranged in some architectural pattern), and fetal cells (larger cells with abundant cytoplasm, smaller than mature hepatocytes).
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DARIER's Disease = This solitary keratotic papule has a somewhat endophytic growth pattern, with a central plug of keratin. There is both acantholysis and dyskeratosis. There is suprabasal acantholysis over a papillomatous superficial dermis. Above the suprabasal acantholysis, there are large, eosinophilic, rounded suprabasal cells with perinuclear halos (Corps Ronds). Above these are small dark cells with pyknotic nuclei and a millet-seed-like by bernadine
bernadine
bernadine DARIER's Disease = This solitary keratotic papule has a somewhat endophytic growth pattern, with a central plug of keratin. There is both acantholysis and dyskeratosis. There is suprabasal acantholysis over a papillomatous superficial dermis. Above the suprabasal acantholysis, there are large, eosinophilic, rounded suprabasal cells with perinuclear halos (Corps Ronds). Above these are small dark cells with pyknotic nuclei and a millet-seed-like
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PVNS. Mononuclear cells and giant cells. Plasmacytoid nuclei. by tamera
tamera
tamera PVNS. Mononuclear cells and giant cells. Plasmacytoid nuclei.
Nobody Does it Better than Nature
Ewing/PNET. Calf of 11 year old boy.  Some of these cells form rosette-like structures. At high power, the lesion comprises of fairly monotonous, small round blue cells with scant cytoplasm, high N:C ratio, and multiple cytoplasmic vacuoles. The Papanicolaou-stained material demonstrates round to oval nuclei with multiple small nucleoli and occasional mitotic figures. Immunohistochemistry shows that the cells are immunoreactive for CD99 by graciela
graciela
graciela Ewing/PNET. Calf of 11 year old boy. Some of these cells form rosette-like structures. At high power, the lesion comprises of fairly monotonous, small round blue cells with scant cytoplasm, high N:C ratio, and multiple cytoplasmic vacuoles. The Papanicolaou-stained material demonstrates round to oval nuclei with multiple small nucleoli and occasional mitotic figures. Immunohistochemistry shows that the cells are immunoreactive for CD99
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Hairy cell leukemia. Never in nodes. BLOOD: mimics aplastic anemia (has characteristic MONOCYTOPENIA and neutropenia- reason you would die from it). Very few neoplastic cells in blood. DO NOT DIAGNOSE if there are monocytes. Classic cell morphology = bigger, with nucleus 2x size of normal one and the cell size is very uniform, no transformed cells. Nuclei can be round, oval, RENIFORM, or bilobed. Chromatin is very distinct ground glass and NO by carolina
carolina
carolina Hairy cell leukemia. Never in nodes. BLOOD: mimics aplastic anemia (has characteristic MONOCYTOPENIA and neutropenia- reason you would die from it). Very few neoplastic cells in blood. DO NOT DIAGNOSE if there are monocytes. Classic cell morphology = bigger, with nucleus 2x size of normal one and the cell size is very uniform, no transformed cells. Nuclei can be round, oval, RENIFORM, or bilobed. Chromatin is very distinct ground glass and NO
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Marginal zone lymphomas. 1. Nodal = proliferation of monocyoid B cells in a diffuse, sinusoidal or interfollicular pattern, permeates the follicles.  Look for Dutcher bodies (ND- nuclear). 2. MALT = small round lymphs with lots of pale cytoplasm and indented nuclei (monocytoid B cells), plasma cells (ND), and lymphoepithelial lesions. The plasma cells are actually monoclonal!  Also can see regular old reactive follicles, don't be fooled that by dee
dee
dee Marginal zone lymphomas. 1. Nodal = proliferation of monocyoid B cells in a diffuse, sinusoidal or interfollicular pattern, permeates the follicles. Look for Dutcher bodies (ND- nuclear). 2. MALT = small round lymphs with lots of pale cytoplasm and indented nuclei (monocytoid B cells), plasma cells (ND), and lymphoepithelial lesions. The plasma cells are actually monoclonal! Also can see regular old reactive follicles, don't be fooled that
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Neuroblastoma, thoracic mass, 11 month old girl. This tumor differs from PNET in that neuroblastoma cells are variable in size, there is extensive neuropil, and focal ganglion cell differentiation may be seen in the form of cells with an amphophyllic cytoplasm and prominent nucleoli. The cells in PNET would be CD99 positive where as neuroblastoma cells would not. “neuroblastoma, stroma poor, poorly differentiated and low MKI by kim
kim
kim Neuroblastoma, thoracic mass, 11 month old girl. This tumor differs from PNET in that neuroblastoma cells are variable in size, there is extensive neuropil, and focal ganglion cell differentiation may be seen in the form of cells with an amphophyllic cytoplasm and prominent nucleoli. The cells in PNET would be CD99 positive where as neuroblastoma cells would not. “neuroblastoma, stroma poor, poorly differentiated and low MKI
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Signet ring by elvia
Signet Ring by elvia
Lymphoepithelial cyst in thyroid. istologically, they are essentially identifical to branchial cleft cysts located laterally in the neck. The lining epithelium may show any combination of squamous cells, cuboidal cells and even columnar cells with cilia. The most important entity to rule out of the differential diagnosis is a cystic papillary carcinoma where the tumor cells have undergone extensive squamous metaplasia. by claudine
claudine
claudine Lymphoepithelial cyst in thyroid. istologically, they are essentially identifical to branchial cleft cysts located laterally in the neck. The lining epithelium may show any combination of squamous cells, cuboidal cells and even columnar cells with cilia. The most important entity to rule out of the differential diagnosis is a cystic papillary carcinoma where the tumor cells have undergone extensive squamous metaplasia.
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TREMETSKI.COM: MOST COMMON TREATMENT FOR SKIN CANCER - Basal cell carcinoma is a form of skin cancer caused by regular sun exposure, or other ultraviolet radiation, which starts in the top layer of the skin (epidermis by lottie
lottie
lottie TREMETSKI.COM: MOST COMMON TREATMENT FOR SKIN CANCER - Basal cell carcinoma is a form of skin cancer caused by regular sun exposure, or other ultraviolet radiation, which starts in the top layer of the skin (epidermis
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Buy Single Bright Brass Shower Curtain Ring with Roller Balls by BathProduct2
BathProduct2
BathProduct2 Buy Single Bright Brass Shower Curtain Ring with Roller Balls
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5 Reasons to Ditch Dryer Sheets & Switch to Wool Dryer Balls - I've been using mine for several months now and I'll never go back to dryer sheets! by cristina
cristina
cristina 5 Reasons to Ditch Dryer Sheets & Switch to Wool Dryer Balls - I've been using mine for several months now and I'll never go back to dryer sheets!
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Epithelioid sarcoma. The tumor lesion on low power has the morphology of a palisaded necrotizing granuloma. There appears to be central collagenous necrobiosis, and the lesional cells simulate histiocytes surrounding this necrobiosis. However, the surrounding cells demonstrate fairly prominent nucleoli, and mitotic figures are evident. These cells label for both cytokeratin (shown below) and CD34, establishing the diagnosis of epithelioid sarcoma. by lacey
lacey
lacey Epithelioid sarcoma. The tumor lesion on low power has the morphology of a palisaded necrotizing granuloma. There appears to be central collagenous necrobiosis, and the lesional cells simulate histiocytes surrounding this necrobiosis. However, the surrounding cells demonstrate fairly prominent nucleoli, and mitotic figures are evident. These cells label for both cytokeratin (shown below) and CD34, establishing the diagnosis of epithelioid sarcoma.
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Squamous cell CA in pap smear. large cells with high N:C ratios and macronucleoli. by brittney
brittney
brittney Squamous cell CA in pap smear. large cells with high N:C ratios and macronucleoli.
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Fill a silver bowl with shining beads, a pillar candle and several medium-sized glass balls. by FATIMA CACIQUE
FATIMA CACIQUE
FATIMA CACIQUE Fill a silver bowl with shining beads, a pillar candle and several medium-sized glass balls.
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A DELICATE ART DECO EMERALD AND DIAMOND BRACELET, BY CARTIER   The central panel set with three rectangular-shaped emeralds within a by rose.maurer.14
rose.maurer.14
rose.maurer.14 A DELICATE ART DECO EMERALD AND DIAMOND BRACELET, BY CARTIER The central panel set with three rectangular-shaped emeralds within a
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Simple & affordable small house plan with open plan and three bedrooms. by mrs. sparkle
mrs. sparkle
mrs. sparkle Simple & affordable small house plan with open plan and three bedrooms.
martis home
Small House Plan with three bedrooms, and open planning. Floor Plan from ConceptHome.com by Kay Berry
Kay Berry
Kay Berry Small House Plan with three bedrooms, and open planning. Floor Plan from ConceptHome.com
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Simple & affordable small house plan with open plan and three bedrooms. by proteamundi
proteamundi
proteamundi Simple & affordable small house plan with open plan and three bedrooms.
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Lung cells. Immunofluorescence light micrograph of pulmonary endothelial cells. Endothelial cells are specialized epithelial cells that line the inner surface of blood vessels. Nuclei, which contain the cell's genetic information, are purple; actin filaments, which are major components of the cytoskeleton, are cyan; mitochondria, which generate energy for the cell, are white. © Dr. Torsten Wittmann / Science Source #lungcells #pulmonary #micrograph #sciencephotos #stockimages #sciencesource by katharine
katharine
katharine Lung cells. Immunofluorescence light micrograph of pulmonary endothelial cells. Endothelial cells are specialized epithelial cells that line the inner surface of blood vessels. Nuclei, which contain the cell's genetic information, are purple; actin filaments, which are major components of the cytoskeleton, are cyan; mitochondria, which generate energy for the cell, are white. © Dr. Torsten Wittmann / Science Source #lungcells #pulmonary #micrograph #sciencephotos #stockimages #sciencesource
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Medieval silver signet ring with lion, circa 11th - 13th century by cheri
cheri
cheri Medieval silver signet ring with lion, circa 11th - 13th century
Celebs - all sorts
canalicular adenoma on lip. it is characterized by double columns of cells forming interconnecting channels that course through a loose myxoid stroma. The cells forming the channels have columnar, uniformly aligned nuclei without atypia or mitotic activity. it has a striking predilection for the upper lip. Although a rare salivary gland tumor overall, they are outnumbered only by pleomorphic adenomas at this specific site. by graciela
graciela
graciela canalicular adenoma on lip. it is characterized by double columns of cells forming interconnecting channels that course through a loose myxoid stroma. The cells forming the channels have columnar, uniformly aligned nuclei without atypia or mitotic activity. it has a striking predilection for the upper lip. Although a rare salivary gland tumor overall, they are outnumbered only by pleomorphic adenomas at this specific site.
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Astral Plane Signet Ring by angelina
angelina
angelina Astral Plane Signet Ring
Jewelry
Signet Rock Ring by maude
maude
maude Signet Rock Ring
Jewelry
Three lenses to use with your cell phone (any cell phone). They attach with a magnetic ring. Come in fisheye, telephoto, and wide/macro. by jamie_1
jamie_1
jamie_1 Three lenses to use with your cell phone (any cell phone). They attach with a magnetic ring. Come in fisheye, telephoto, and wide/macro.
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Turquoise Chip Signet Ring by One Kings Lane
One Kings Lane
One Kings Lane Turquoise Chip Signet Ring
Vintage Rings (Fine)