Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini
Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam)
Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm)
Signet ring cells or intercellular glandular lumens by rochelle
rochelle
rochelle Pancreatic ductal adeno. Flat sheets of cells, three dimensional balls, and microacini Columnar cells with delicate cytoplasm and polar nuclei (basal nuclei, apical cytoplsam) Open chromatin with prominent central single nucleolus (versus squamous cell carcinoma with nuclei with dense chromatin and several small nucleoli, and dense cytoplasm) Signet ring cells or intercellular glandular lumens
bargain
Hepatoblastoma. Three cell types. undifferentiated (small cells reminiscent of neuroblastoma or Wilms tumor), embryonal cells (slightly more mature cells with large nuclei, scant cytoplasm, arranged in some architectural pattern), and fetal cells (larger cells with abundant cytoplasm, smaller than mature hepatocytes). by marcie
marcie
marcie Hepatoblastoma. Three cell types. undifferentiated (small cells reminiscent of neuroblastoma or Wilms tumor), embryonal cells (slightly more mature cells with large nuclei, scant cytoplasm, arranged in some architectural pattern), and fetal cells (larger cells with abundant cytoplasm, smaller than mature hepatocytes).
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Ewing/PNET. Calf of 11 year old boy.  Some of these cells form rosette-like structures. At high power, the lesion comprises of fairly monotonous, small round blue cells with scant cytoplasm, high N:C ratio, and multiple cytoplasmic vacuoles. The Papanicolaou-stained material demonstrates round to oval nuclei with multiple small nucleoli and occasional mitotic figures. Immunohistochemistry shows that the cells are immunoreactive for CD99 by graciela
graciela
graciela Ewing/PNET. Calf of 11 year old boy. Some of these cells form rosette-like structures. At high power, the lesion comprises of fairly monotonous, small round blue cells with scant cytoplasm, high N:C ratio, and multiple cytoplasmic vacuoles. The Papanicolaou-stained material demonstrates round to oval nuclei with multiple small nucleoli and occasional mitotic figures. Immunohistochemistry shows that the cells are immunoreactive for CD99
Spend
Mesothelioma = large complex cell clusters with KNOBBY border. Cell in cell arrangements. Single cells with dense perinuclear cytoplasm and lacy cytoplasm.  POS for calretinin, EMA, Alcian blue, CK 5/6, CAM 5.2 and only PAS (glycogen).  Neg for PAS-D (glycogen is dissolved), BerEp4, B72.3, CD15, mucicarmine. Have long branching slender microvilli on EM. Can have collagen balls and lymphs. by alma
alma
alma Mesothelioma = large complex cell clusters with KNOBBY border. Cell in cell arrangements. Single cells with dense perinuclear cytoplasm and lacy cytoplasm. POS for calretinin, EMA, Alcian blue, CK 5/6, CAM 5.2 and only PAS (glycogen). Neg for PAS-D (glycogen is dissolved), BerEp4, B72.3, CD15, mucicarmine. Have long branching slender microvilli on EM. Can have collagen balls and lymphs.
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Neuroblastoma, thoracic mass, 11 month old girl. This tumor differs from PNET in that neuroblastoma cells are variable in size, there is extensive neuropil, and focal ganglion cell differentiation may be seen in the form of cells with an amphophyllic cytoplasm and prominent nucleoli. The cells in PNET would be CD99 positive where as neuroblastoma cells would not. “neuroblastoma, stroma poor, poorly differentiated and low MKI by kim
kim
kim Neuroblastoma, thoracic mass, 11 month old girl. This tumor differs from PNET in that neuroblastoma cells are variable in size, there is extensive neuropil, and focal ganglion cell differentiation may be seen in the form of cells with an amphophyllic cytoplasm and prominent nucleoli. The cells in PNET would be CD99 positive where as neuroblastoma cells would not. “neuroblastoma, stroma poor, poorly differentiated and low MKI
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DARIER's Disease = This solitary keratotic papule has a somewhat endophytic growth pattern, with a central plug of keratin. There is both acantholysis and dyskeratosis. There is suprabasal acantholysis over a papillomatous superficial dermis. Above the suprabasal acantholysis, there are large, eosinophilic, rounded suprabasal cells with perinuclear halos (Corps Ronds). Above these are small dark cells with pyknotic nuclei and a millet-seed-like by bernadine
bernadine
bernadine DARIER's Disease = This solitary keratotic papule has a somewhat endophytic growth pattern, with a central plug of keratin. There is both acantholysis and dyskeratosis. There is suprabasal acantholysis over a papillomatous superficial dermis. Above the suprabasal acantholysis, there are large, eosinophilic, rounded suprabasal cells with perinuclear halos (Corps Ronds). Above these are small dark cells with pyknotic nuclei and a millet-seed-like
Getting
PVNS. Mononuclear cells and giant cells. Plasmacytoid nuclei. by tamera
tamera
tamera PVNS. Mononuclear cells and giant cells. Plasmacytoid nuclei.
Nobody Does it Better than Nature
Scrotum. Granular cell tumor. S100 positive, CD68 positive, inhibin positive. Lysosomes on EM. uvenile xanthogranuloma features histiocytic cells which merge with those with features of Touton-like giant cells. This lesion labels for CD68, but not for S100 or CD1a. Langerhans histiocytosis is composed of cells with more reniform nuclei, and the lesional cells label for CD1a. by carolina
carolina
carolina Scrotum. Granular cell tumor. S100 positive, CD68 positive, inhibin positive. Lysosomes on EM. uvenile xanthogranuloma features histiocytic cells which merge with those with features of Touton-like giant cells. This lesion labels for CD68, but not for S100 or CD1a. Langerhans histiocytosis is composed of cells with more reniform nuclei, and the lesional cells label for CD1a.
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Marginal zone lymphomas. 1. Nodal = proliferation of monocyoid B cells in a diffuse, sinusoidal or interfollicular pattern, permeates the follicles.  Look for Dutcher bodies (ND- nuclear). 2. MALT = small round lymphs with lots of pale cytoplasm and indented nuclei (monocytoid B cells), plasma cells (ND), and lymphoepithelial lesions. The plasma cells are actually monoclonal!  Also can see regular old reactive follicles, don't be fooled that by dee
dee
dee Marginal zone lymphomas. 1. Nodal = proliferation of monocyoid B cells in a diffuse, sinusoidal or interfollicular pattern, permeates the follicles. Look for Dutcher bodies (ND- nuclear). 2. MALT = small round lymphs with lots of pale cytoplasm and indented nuclei (monocytoid B cells), plasma cells (ND), and lymphoepithelial lesions. The plasma cells are actually monoclonal! Also can see regular old reactive follicles, don't be fooled that
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Hairy cell leukemia. Never in nodes. BLOOD: mimics aplastic anemia (has characteristic MONOCYTOPENIA and neutropenia- reason you would die from it). Very few neoplastic cells in blood. DO NOT DIAGNOSE if there are monocytes. Classic cell morphology = bigger, with nucleus 2x size of normal one and the cell size is very uniform, no transformed cells. Nuclei can be round, oval, RENIFORM, or bilobed. Chromatin is very distinct ground glass and NO by carolina
carolina
carolina Hairy cell leukemia. Never in nodes. BLOOD: mimics aplastic anemia (has characteristic MONOCYTOPENIA and neutropenia- reason you would die from it). Very few neoplastic cells in blood. DO NOT DIAGNOSE if there are monocytes. Classic cell morphology = bigger, with nucleus 2x size of normal one and the cell size is very uniform, no transformed cells. Nuclei can be round, oval, RENIFORM, or bilobed. Chromatin is very distinct ground glass and NO
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Xp11 translocation renal cell carcinoma, 18 year old female. This tumor is composed of clear cells with abundant cytoplasm. The architecture is both papillary and nested. Psammoma bodies were found elsewhere. Given a tumor with both clear cells and papillary architecture in a patient of this young age, Xp11 Translocation Carcinoma becomes a serious diagnostic consideration. The diagnosis is confirmed by immunohistochemistry, revealing nuclear labeling for TFE3 protein. by maxine
maxine
maxine Xp11 translocation renal cell carcinoma, 18 year old female. This tumor is composed of clear cells with abundant cytoplasm. The architecture is both papillary and nested. Psammoma bodies were found elsewhere. Given a tumor with both clear cells and papillary architecture in a patient of this young age, Xp11 Translocation Carcinoma becomes a serious diagnostic consideration. The diagnosis is confirmed by immunohistochemistry, revealing nuclear labeling for TFE3 protein.
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Signet Ring by Pinky and the Brain
Adenocarcinoma. The cell in focus is comprised of a large nucleus, promininent nucleoli with an eccentric cytoplasm, suggesting glandular differentiation. Another fragment is shown with cells in a cohesive group with subtle cell borders. The nuclear outlines are irregular, and each contains a prominent nucleoli. The degree of atypia is consistent with an adenocarcinoma. The clean smear background is suggestive of a metastasis. by brittney
brittney
brittney Adenocarcinoma. The cell in focus is comprised of a large nucleus, promininent nucleoli with an eccentric cytoplasm, suggesting glandular differentiation. Another fragment is shown with cells in a cohesive group with subtle cell borders. The nuclear outlines are irregular, and each contains a prominent nucleoli. The degree of atypia is consistent with an adenocarcinoma. The clean smear background is suggestive of a metastasis.
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Signet Ring by elvia
Delicate and lovely, this 14-karat-gold style made with Lana's signature flat-edge chains features three open disc pendants for a modern, sculptural effect. Style Name: Lana Jewelry Open Disc Frontal Necklace. Style Number: 5370714. Available in $380.98 by nordstrom
nordstrom
nordstrom Delicate and lovely, this 14-karat-gold style made with Lana's signature flat-edge chains features three open disc pendants for a modern, sculptural effect. Style Name: Lana Jewelry Open Disc Frontal Necklace. Style Number: 5370714. Available in $380.98
Women
Three lenses to use with your cell phone (any cell phone). They attach with a magnetic ring. Come in fisheye, telephoto, and wide/macro. $50.00 for all three. by lauren
lauren
lauren Three lenses to use with your cell phone (any cell phone). They attach with a magnetic ring. Come in fisheye, telephoto, and wide/macro. $50.00 for all three.
Amazing photography
TREMETSKI.COM: MOST COMMON TREATMENT FOR SKIN CANCER - Basal cell carcinoma is a form of skin cancer caused by regular sun exposure, or other ultraviolet radiation, which starts in the top layer of the skin (epidermis by lottie
lottie
lottie TREMETSKI.COM: MOST COMMON TREATMENT FOR SKIN CANCER - Basal cell carcinoma is a form of skin cancer caused by regular sun exposure, or other ultraviolet radiation, which starts in the top layer of the skin (epidermis
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The picture shows small cell carcinoma of hypercalcemic type.  Most tumors present as advanced disease, with only 1/3 presenting as stage I tumors.  62% of small cell carcinomas of hypercalcemic type are associated with elevated serum calcium levels.  Rare dysgerminomas may also present with hypercalcemia. Prognosis is poor, with only 1/3 of stage Ia patients having disease-free followup periods.  These tumors are typically positive for EMA and by nanette
nanette
nanette The picture shows small cell carcinoma of hypercalcemic type. Most tumors present as advanced disease, with only 1/3 presenting as stage I tumors. 62% of small cell carcinomas of hypercalcemic type are associated with elevated serum calcium levels. Rare dysgerminomas may also present with hypercalcemia. Prognosis is poor, with only 1/3 of stage Ia patients having disease-free followup periods. These tumors are typically positive for EMA and
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Lymphoepithelial cyst in thyroid. istologically, they are essentially identifical to branchial cleft cysts located laterally in the neck. The lining epithelium may show any combination of squamous cells, cuboidal cells and even columnar cells with cilia. The most important entity to rule out of the differential diagnosis is a cystic papillary carcinoma where the tumor cells have undergone extensive squamous metaplasia. by claudine
claudine
claudine Lymphoepithelial cyst in thyroid. istologically, they are essentially identifical to branchial cleft cysts located laterally in the neck. The lining epithelium may show any combination of squamous cells, cuboidal cells and even columnar cells with cilia. The most important entity to rule out of the differential diagnosis is a cystic papillary carcinoma where the tumor cells have undergone extensive squamous metaplasia.
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Simple & affordable small house plan with open plan and three bedrooms. by proteamundi
proteamundi
proteamundi Simple & affordable small house plan with open plan and three bedrooms.
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5 Reasons to Ditch Dryer Sheets & Switch to Wool Dryer Balls - I've been using mine for several months now and I'll never go back to dryer sheets! by SundayLady
SundayLady
SundayLady 5 Reasons to Ditch Dryer Sheets & Switch to Wool Dryer Balls - I've been using mine for several months now and I'll never go back to dryer sheets!
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Epithelioid sarcoma. The tumor lesion on low power has the morphology of a palisaded necrotizing granuloma. There appears to be central collagenous necrobiosis, and the lesional cells simulate histiocytes surrounding this necrobiosis. However, the surrounding cells demonstrate fairly prominent nucleoli, and mitotic figures are evident. These cells label for both cytokeratin (shown below) and CD34, establishing the diagnosis of epithelioid sarcoma. by lacey
lacey
lacey Epithelioid sarcoma. The tumor lesion on low power has the morphology of a palisaded necrotizing granuloma. There appears to be central collagenous necrobiosis, and the lesional cells simulate histiocytes surrounding this necrobiosis. However, the surrounding cells demonstrate fairly prominent nucleoli, and mitotic figures are evident. These cells label for both cytokeratin (shown below) and CD34, establishing the diagnosis of epithelioid sarcoma.
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Small House Plan with three bedrooms, and open planning. Floor Plan from ConceptHome.com by Kay Berry
Kay Berry
Kay Berry Small House Plan with three bedrooms, and open planning. Floor Plan from ConceptHome.com
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pretty slim signet ring by terrand
terrand
terrand pretty slim signet ring
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watch + bracelets + signet ring by doreen.m
doreen.m
doreen.m watch + bracelets + signet ring
Style
Squamous cell CA in pap smear. large cells with high N:C ratios and macronucleoli. by brittney
brittney
brittney Squamous cell CA in pap smear. large cells with high N:C ratios and macronucleoli.
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Antigua Mini Dress | High neck mini dress featuring an open back with delicate button closures and hip pockets. Three-quarter length sleeves with s� | Pinterest by french_violet
french_violet
french_violet Antigua Mini Dress | High neck mini dress featuring an open back with delicate button closures and hip pockets. Three-quarter length sleeves with s� | Pinterest
Dress Me Up
A DELICATE ART DECO EMERALD AND DIAMOND BRACELET, BY CARTIER   The central panel set with three rectangular-shaped emeralds within a by rose.maurer.14
rose.maurer.14
rose.maurer.14 A DELICATE ART DECO EMERALD AND DIAMOND BRACELET, BY CARTIER The central panel set with three rectangular-shaped emeralds within a
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In Miniature        A pillar candle surrounded by several smaller accents creates an elegant display. The candle inside the clear glass hurricane stands tall amidst small vessels filled with water and a single flower or sprig of foliage. Red metallic florist's picks and loose silver ornaments add color and sparkle. by catrulz
catrulz
catrulz In Miniature A pillar candle surrounded by several smaller accents creates an elegant display. The candle inside the clear glass hurricane stands tall amidst small vessels filled with water and a single flower or sprig of foliage. Red metallic florist's picks and loose silver ornaments add color and sparkle.
Christmas
Simple & affordable small house plan with open plan and three bedrooms. by mrs. sparkle
mrs. sparkle
mrs. sparkle Simple & affordable small house plan with open plan and three bedrooms.
martis home
Fill a silver bowl with shining beads, a pillar candle and several medium-sized glass balls. by FATIMA CACIQUE
FATIMA CACIQUE
FATIMA CACIQUE Fill a silver bowl with shining beads, a pillar candle and several medium-sized glass balls.
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